EKSTRAK RIMPANG KUNYIT (Curcuma longa Linn) MENURUNKAN PENYAKIT PERLEMAKAN HATI NON-ALKOHOLIK

Karmila Kaban(1*), sunarti sunarti(2),


(1) Universitas Prima Indonesia
(2) Universitas Prima Indonesia
(*) Corresponding Author

Abstract


The use of recycled frying oil or deep frying oil (DFO) lead to increase in free fatty acid, trans fatty acid and free radical compound. It can cause non-alcoholic fatty liver disease (NAFLD). a chronic liver disease cause the risk for cirrhosis and heart cancer. However, there is no medicine for preventing the disease. The present study was conducted to investigate the turmeric reduces steatosis hepatocyte of male Wistar rat NAFLD model. The study used experimental randomize post-test only control group design. The 24 samples consist of four treatment groups. Group I (control): normal diet + DFO (10 μl/g/day on 6 times heating), Group II, III and IV: normal diet + DFO (10 μl/g/day on 6 times heating)+ turmeric Extract (100, 200, and 400 mg/kg/day) by given for 30 days through oral induction. The results of Kruskal-Wallis test showed a significant difference between the four treatment groups (P= 0.019) .The results of Mann-Whitney test showed significant difference in steatosis hepatocyte between the control group (P1) and treatment group(P3) the dose of 200 mg/kg BW. This suggests that a dose of 200 mg/kg BW is an effective dose in decreasing hepatocyte steatosis.

Keywords


DFO, NAFLD, Turmeric Extract, Steatosis

Full Text:

PDF

References


Akram, M., Uddin, S., Ahmed, A., Usmanghani, K., Hannan, A., Mohiuddin, E., Asif, M. (2010). Curcuma Longa And Curcumin: A Review Article. J. Biol Plant Biol. 55 (2): 65-70

Astari, A.N., Decroli, E., Yerizel, E. (2015). Gambaran NAFLD Pada Pasien Dengan Sindrom Metabolik di Poliklinik Penyakit Dalam RSUP Dr. M. Djamil Padang. UNAND: Padang. 4 (2)

Brunt, E. M. (2016). Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation Review, Int. J. Mol. Sci. 17 (97): 1-10

Chalasani, N., Younossi, Z., Lavine, E.J., Diehl, M.A., Brunt, M.E., Cusi, K., Chartlton, M., Sanyal, A. J. (2012). The Diagnosis and Management of Non-Alcoholic Fatty Liver Disease. Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology, and the American Gastroenterological Association. 55 (6): 2005-2023

Chowdhury, A and Younossi, Z. (2016). Global Epidemiology and RiskFactors for Non-Alcoholic FattyLiver Disease.Springer International Publishing: Switzerland

Dhibi, M., Brahmi, F., Mnari, A., Houas, Z., Chargui, I., Linda, B., Gazzah, N.,

Alsaif, M., Hammami, M. (2011). The Intake of High Fat Diet With Different Trans Fatty Acid Levels Differentially Induces Oxidative Stress and Non-Alcoholic Fatty Liver Disease (NAFLD) in Rats. BioMed Central. 8 (65): 1-12

Dahlan, M. S. (2011). Statistik Untuk Kedokteran Dan Kesehatan Edisi5. Salemba Medika: Jakarta

Dewi Rosita, Sutejo Ika, R. (2011). Pemberian Minyak Goreng Bekas Pakai Dalam Menimbulkan Kerusakan Sel-Sel Hati Mencit danPenurunan Kadar Albumin Serum Mencit. Moluca Medica. 4: 61 -69

Edwar, Z., Suyuthie, H., Yerizel, E., Sulastri, D. (2011). Pengaruh Pemanasan Terhadap Kejenuhan Asam Lemak Minyak Goreng Sawit dan Minyak Goreng Jagung. J Indon Med Assoc. 61 (6): 248-252

Kelishadi, R., Farajian, S., Mirlohi, M. (2013). Probiotics As A Novel Treatment for Non-Alcoholic Fatty Liver Disease; A Systematic Review on the Current Evidences. Hepat Mon. 13 (4) : 1-8

Ketaren, S. (2012). Pengantar Tehnologi Minyak dan Lemak Pangan. Jakarta: UI Press

Laura, H.,Tetri., Basaranoglu. M., Brunt, E.M.,Yerian, L.M., Neuschwander. B.A. (2008). Severe NAFLD with Hepatic Necro inflammatory Changes in Mice Trans Fats and A High-Fructose Corn Syrup Equivalent. AJP Gastrointest Liver physiol. 293: 987-995

Hamidpour, R., Hamidpour, S., Hamidpour, M., Sohraby, M., Hamidpour, M. (2015). Turmeric (Curcuma longa): from a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-cancer, and anti-diabetes, International Journal of Pharmacology. Phytochemistry and Ethnomedicine. 1: 37-45

Inzaugarat, M, E., Matteo, E., Baz, P., Lucero, D., Garcıa, C., Ballerga, E, G., Daruich, J., Sorda, J, A., Wald, M, R., Chernavsky, A, C. (2017). New evidence for the therapeutic Potential of curcumin to treat nonalcoholic fatty liver disease in humans, Plos One: 5-15

Mahmudan, A., Nisa, F,C. (2017). Efek Penggorengan Kentang Dengan Oven Microwave Terhadap Karakteristik Fisik Dan Kimia Minyak Kelapa Sawit Sawit (Elaeis guineensis), Jurnal Pangan dan Agroindustri.2 (3): 151-160

Novianti, A., Dharmana, E., Widyastiti. (2017). Melatonin menurunkan berat badan tetapi tidak menurunkan kadar TNF-α pada tikus wistar jantan yang diberi minyak jelantah selama 28 hari. Jurnal Gizi Indonesia. 5 (2): 127-132

Patonah, Yunarto, A., Nurhandayani, C. (2016). Aktifitas Curcuma Longa And Curcumin: A Review Article. Jurnal Farmasi Galenika. 01 (02): 54-60

Setiawan, A. (2014). Pemberian Alpha Lipoic Acid Oral Menghambat Peningkatan Jumlah Steatosis dan Kadar ALT Pada Tikus Wistar Jantan Yang Diberi Minyak Jelantah: Tesis. Universitas Udayana : Denpasar

Siswanto, W., Mulasari, S. A. (2015). Pengaruh Frekuensi Penggorengan Terhadap Peningkatan Peroksida Minyak Goreng Curah dan Fortifikasi Vitamin A. Kesmas, 9 (1): 1-10

Suparmajid, A., Sabang, S, M., Ratman. (2016). Pengaruh Lama Penyimpanan Rimpang Kunyit (Curcuma domestica Vahl) Terhadap Daya Hambat Antioksidan. J. Akad. Kim. 5 (1): 2477-5185

Susianti. (2014). Pengaruh Minyak Goreng Bekas Yang Dimurnikan Dengan Buah Mengkudu (Morinda citrifolia) Terhadap Gambaran Histopatology Hepar dan Jantung Tikus. MKA. 37 (2): 54-60

Wahab, A. W., Dewang, S., Armynah, B., Ponganan, K. (2011). Analisis Spektrum Infra Merah Dari Minyak Goreng Kelapa Untuk Identifikasi Perubahan Panjang Gelombang Akibat Variasi Temperatur. UNHAS: Makasar

Wong-Yee , Yusadli, Nurdiyana, Amarina. (2014). Extraction of Essential Oil from Curcuma Longa. J. Food Chem Nutr: 01-10




DOI: http://dx.doi.org/10.31289/biolink.v5i2.1800

Article Metrics

Abstract view : 0 times
PDF - 0 times

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

BIOLINK: JURNAL BIOLOGI LINGKUNGAN,INDUSTRI, KESEHATAN
Program Studi Biologi, Fakultas Biologi, Universitas Medan Area
Universitas Medan Area, Jalan Kolam No. 1, Pasar V, Medan Estate, Sumatera Utara http://ojs.uma.ac.id/index.php/biolink dan Email: biolink@uma.ac.id
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License