HUBUNGAN KADAR TARTRAZIN DAN SENG (ZN) DALAM DARAH PADA ANAK PENDERITA DEFISIT PERHATIAN DAN GANGGUAN HIPERAKTIVITAS (ADHD)

Melvariani Syari Batubara(1*), Yahwardiah Siregar(2), Herla Rusmarilin(3), Sri Soviani(4), Husnarika Febriani(5),


(1) Universitas Muhammadiyah Tapanulli Selatan
(2) Universitas Sumatera Utara
(3) Universitas Sumatera Utara
(4) Universitas Sumatera Utara
(5) Universitas Islam Sumatera Utara
(*) Corresponding Author

Abstract


This research aims to study Tartrazine and Zinc (Zn) status in blood sample of Attention Deficit Hyperactivity Disorder (ADHD) children. Deductive research using the descriptive method through 3 stage, namely : 1. Taken of blood sample, 2. Analysis of Tartrazine status in blood sample was performed by using High Performance Liquid Chromatograpy (HPLC) method, and 3. Analysis of Zinc (Zn) status in blood sample were measurements by using Atomic Adsorbance Spectrophotometry (AAS) method. Data were analyzed using descriptive analysis techniques and Chi Square tests (X2) by Computer programs (SPSS 15). The result of the assessment of Tartrazine status in blood sample of ADHD children that had been was considered statistically highly significant a increase of the assessment of Tartrazine status in blood sample of ADHD children by 130 mg/ml compared with laboratory reference (control) by 28 mg/ml, HA>C** (p<0,001). The result of the assessment of Zinc (Zn) status in blood sample of ADHD children that had been was showed statistically highly significant a reduce of the assessment of Zinc (Zn) status in blood sample of ADHD children by 0,37 µg/ml compared with laboratory reference (control) by 0,64-1,18 µg/ml, HA<C** (p<0,001). This was considered a reduction and increase in Tartrazine and Zinc (Zn) concentrations induces of the Hyperactivity children by 95%.

Keywords


Tartrazin, Seng (Zn), Attention Deficit and Hyperactivity Disorders (ADHD)

Full Text:

PDF

References


Arnold, E. L. & Robert, A. D. (2005). Zinc in Attention-Deficit/Hyperactivivity Disorder. Journal of Child and Adolescent Psychopharmacology. 2005. 15 (4) : 619-627.

Bekaroğlu, M., Y. Asian, Y. Gedik, O. Değer, H. Mocan, E. Erduran & C. Karahan.(1996). Relationships Between Serum Free Fatty Acids and Zinc, and Attention Deficit Hyperactivity Disorder : A Research Note. Journal of Child Psychology and Psychiatry. 1996 ; 37 (2) : 225-227.

Brough, H., R. Alkurdi, R. Nataraja & A. Surendranathan. (2007). Rujukan Cepat Pediatri & Kesehatan Anak. Penerbit Buku Kedokteran EGC : Jakarta. Hal 95-96.

David, T. J. Reactions to dietary tartrazine. (1987). Arch Dis Child. 62 : 119-122.

Departemen Kesehatan Republik Indonesia. (1995). Farmakope Indonesia. Edisi keempat. 1995. Hal 723-967.

Devlin, J. & T. J. David. Tartrazine in atopic eczema. (1992). Arch Dis Child; 67 : 709-711.

European Food Safety Authority (EFSA) Panel on Food Additives and Nutrient Sources added to Food (ANS). (2009). Scientific Opinion on the re-evaluation Tartrazine (E 102). EFSA Journal. 2009 ; 7 (11) : 1331.

Flavour Master Limited. Tartrazine. (2002). Heaton, S. Focus on Organic Food Quality : Food Additives. Australian Organic Journal. 2002 ; 10-12.

Insley, J. (2003). Vade-Mecum Pediatri. Edisi ketiga belas. Penerbit Buku Kedokteran EGC : Jakarta. Hal 321.

Markum A. H. (1991). Buku Ajar Ilmu Kesehatan Anak. Jilid 1. Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia : Jakarta. Hal 122-184.

Nelson, W. E., R. E. Behrman, R. Kliegman & A. M. Arvin. (2000). Nelson Ilmu Kesehatan Anak. Edisi kelimabelas. Vol. 1 & 3. Penerbit Buku Kedokteran EGC : Jakarta. Hal 114-224 & 2501.

Santoso, G. (2005). Fundamental Metodologi Penelitian Kuantitatif dan Kualitatif. Prestasi Pustaka Publisher : Jakarta. Hal 21-61.

Sinn, N. (2008). Nutritional and Dietary Influences on Attention Deficit Hyperactivity Disorder. Nutrition Reviews. 66 (10) : 558-568.

Tayade, H. P., Mandlik R. V. & Patil M. R. Hidden. (2006). Hazards Of Artificial Colours And Flavours Used in Pharmaceutical Preparations.

Ward, N. I., K. A. Soulsbury, V. H. Zettel, I. D. Colquhoun, S. Bunday & B. Barnes. (1990). The Influence of the Chemical Additive Tartrazine on the Zinc Status of Hyperactive Children a Double-blind Placebo-controlled Study. Journal of Nutritional Medicine. 1990 ; 1 (1) : 51-57.

Ward, N. I. (1997). Assessment of Chemical Factors in Relation to Child Hyperactivity. Journal of Nutritional & Environmental Medicine. 1997 ; 7 : 333-342.




DOI: http://dx.doi.org/10.31289/biolink.v4i1.960

Article Metrics

Abstract view : 2877 times
PDF - 48 times

Refbacks

  • There are currently no refbacks.


BIOLINK: JURNAL BIOLOGI LINGKUNGAN,INDUSTRI, KESEHATAN
Program Studi Biologi, Fakultas Biologi, Universitas Medan Area
Universitas Medan Area, Jalan Kolam No. 1, Pasar V, Medan Estate, Sumatera Utara http://ojs.uma.ac.id/index.php/biolink dan Email: biolink@uma.ac.id
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License