EFFECTIVENESS OF PURSULA (Portulaca oleracea) FATTY ACID EXTRACTS IN REDUCE THE TRIGLYCERIDES OF OBESITY RATS

Atok Miftachul Hudha; Larasati Dwi Cahyaning Putri; Fendy Hardian Permana

doi:10.31289/biolink.v10i1.9055

EFFECTIVENESS OF PURSULA (Portulaca oleracea) FATTY ACID EXTRACTS IN REDUCE THE TRIGLYCERIDES OF OBESITY RATS

Authors

Atok Miftachul Hudha , Larasati Dwi Cahyaning Putri , Fendy Hardian Permana

DOI:

10.31289/biolink.v10i1.9055

Published:

2023-08-14

Issue:

Vol. 10 No. 1 (2023): August

Keywords:

Portulaca Oleracea, Omega-3, Triglyceride Levels, Obese Rat, Hyperlipidemia

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Atok Miftachul Hudha, Larasati Dwi Cahyaning Putri, & Fendy Hardian Permana. (2023). EFFECTIVENESS OF PURSULA (Portulaca oleracea) FATTY ACID EXTRACTS IN REDUCE THE TRIGLYCERIDES OF OBESITY RATS. BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan), 10(1), 99–107. https://doi.org/10.31289/biolink.v10i1.9055

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Abstract

Hyperlipidemia is a condition of high levels of lipids in the blood. Hyperlipidemia is a major factor causing non-communicable diseases such as DMT2 and stroke. Purslane is a plant that contains PUFA which is hypolipidemic. The purpose of this study was to test the effectiveness of giving purslane plant fatty acid extracts in reducing triglyceride levels in obese rats induced by a high-fat and high-calorie diet. There were five treatments in this study, namely P1 negative control (no treatment), P2 positive control (by administering gemfibrozil), P3 (100 mg/kg BW of purslane fatty acid extract), P4 (200 mg/kg BW of purslane fatty acid extract), P5 (300 mg/kg BW of purslane fatty acid extract). The test animals used were male rats strain Ratus norvegitus, male, initial body weight ± 200 grams with final body weight ≥ 10% of initial weight. This research is True-Eksperimental Research using a Control Group Pretest-Posttest Design with the RAL experimental design. The data obtained were analyzed statistically using tests Quade's Rank Analysis of Covariance. The results showed that the purslane plant fatty acid extract could reduce triglyceride levels. In this study, a dose of 300 mg/kg BW was the best dose for reducing triglyceride levels in obese rats.

References

Azizah, R. N., Putra, B., & Tobis, R. (2018). Aktivitas Hipolipidemik Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Pada Tikus Obesitas Dengan Parameter Trigliserida. Journal of Chemical Information and Modeling, 53(9), 1689-1699.

Battung, S. M., Salam, A., Novrianti, D., & Ajie, R. A. K. (2019). Efek Diet Tinggi Karbohidrat Terhadap Glukosa Darah Dan Berat Badan Tikus Wistar. Jurnal Gizi Masyarakat Indonesia (The Journal of Indonesian Community Nutrition), 8(2).

Bornfeldt, K. E. (2021). Triglyceride lowering by omega-3 fatty acids: A mechanism mediated by N-acyl taurines. The Journal of Clinical Investigation, 131(6).

Carlos, F. K., Sari, W. P., Kusumawardhani, S., & Tendean, M. (2014). Tatalaksana terkini Dislipidemia. Jurnal Kedokteran Meditek.

Changizi-Ashtiyani, S., Zarei, A., Taheri, S., Rasekh, F., & Ramazani, M. (2013). The effects of Portulaca oleracea alcoholic extract on induced hypercholesteroleomia in rats. Zahedan journal of research in medical sciences, 15(6).

El-Newary, S. A. (2016). The hypolipidemic effect of Portulaca oleracea L. stem on hyperlipidemic Wister Albino rats. Annals of Agricultural Sciences, 61(1), 111-124.

Husein, S. G., Sundalian, M., & Husna, N. (2021). Analisis Komponen Senyawa Kimia Krokot (Portulaca oleraceae L. dan Portulaca grandiflora Hook.): Review: Component Analysis of Purslanes Chemicals Compound (Portulaca oleraceae L. andPortulaca grandiflora Hook.). Jurnal Sains dan Kesehatan, 3(2), 317-327.

Karalis, D. G. (2017). A review of clinical practice guidelines for the management of hypertriglyceridemia: a focus on high dose omega-3 fatty acids. Advances in therapy, 34, 300-323.

Morton, A. M., Furtado, J. D., Lee, J., Amerine, W., Davidson, M. H., & Sacks, F. M. (2016). The effect of omega-3 carboxylic acids on apolipoprotein CIII− containing lipoproteins in severe hypertriglyceridemia. Journal of clinical lipidology, 10(6), 1442-1451.

Noriko, N., Puspitasari, R. L., & Doeana, A. S. (2017). Pengaruh pakan tepung cannalina terhadap pertumbuhan Mus musculus. Jurnal Al-Azhar Indonesia Seri Sains dan Teknologi, 3(1), 54-63.

Putri, S. R., & Anggraini, D. I. (2015). Obesitas sebagai faktor resiko peningkatan kadar trigliserida. Jurnal Majority, 4(9), 78-82.

Rissa, B., Salim, K., Wihandani, D. M., Nyoman, N., & Dewi, A. (2021). Obesitas sebagai faktor risiko terjadinya peningkatan kadar trigliserida dalam darah : tinjauan pustaka. 12(2),519–523. https://doi.org/10.15562/ism.v12i2.1031

Santi, I., & Azizah, R. N. (2018). Penentuan Dosis Minimum Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Terhadap Penurunan Kadar Trigliserida Pada Tikus ObesitaS. As-Syifaa Jurnal Farmasi, 10(2), 205-212.

Sabarinah, S., Fauziah, I., & Anggraeni, D. N. (2019). Prevalensi Penderita Diabetes Melitus Tipe-II pada Pasien di Puskesmas Kota Blangkejeren, Kecamatan Blangkejeren, Kabupaten Gayo Lues Tahun 2015–2017. Jurnal Ilmiah Biologi UMA (JIBIOMA), 1(1), 28-35.

Setiawan, G., & Halim, M. C. (2022). Pengaruh Asam Lemak Omega-3 terhadap Penyakit Kardiovaskular. Cermin Dunia Kedokteran, 49(3), 160-163.

Skulas-Ray, A. C., Wilson, P. W., Harris, W. S., Brinton, E. A., Kris-Etherton, P. M., Richter, C. K., ... & Welty, F. K. (2019). Omega-3 fatty acids for the management of hypertriglyceridemia: a science advisory from the American Heart Association. Circulation, 140(12), e673-e691.

Winato, B. M., Sanjaya, E., Siregar, L., Fau, S. K. Y. M. V., & Mutia, M. S. (2019). Uji Aktivitas Antibakteri Ekstrak Daun Serai Wangi (Cymbopogon Nardus) Terhadap Bakteri Propionibacterium Acnes. BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan), 6(1), 50-58.

Witosari, N., & Widyastuti, N. (2014). Pengaruh pemberian jus daun ubi jalar (Ipomoea batatas (l.) lam) terhadap kadar kolesterol total tikus wistar jantan (Rattus norvegicus) yang diberi pakan tinggi lemak (Doctoral dissertation, Diponegoro University).

Author Biographies

Atok Miftachul Hudha, Universitas Muhammadiyah Malang

Biology Education Study Program, Faculty Of Teacher Training And Education

Larasati Dwi Cahyaning Putri, Universitas Muhammadiyah Malang

Biology Education Study Program, Faculty Of Teacher Training And Education

Fendy Hardian Permana

Universitas Muhammadiyah Malang

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